Important safety information
What you should know before taking Zepbound.
Zepbound® prescription online for weight loss
(tirzepatide) injection
Lose 20% of your body weight on average in 1 year*. See safety info below.
New FDA-approved medication for weight loss (same active ingredient as Mounjaro)
Targets two hormone receptors (GLP-1 and GIP) to maximize weight loss
What is Zepbound?
Zepbound uses the same active ingredient (tirzepatide) as Mounjaro®. It’s a dual-action GLP-1/GIP that is approved by the FDA for people with obesity BMI ≥30, or overweight BMI ≥27 plus a weight-related condition, along with diet and exercise changes.
How is Zepbound different from Ozempic® or Wegovy®?
Zepbound and Wegovy are approved by the FDA for weight loss, while Ozempic is approved for the treatment of type 2 diabetes, but can be prescribed off-label for weight loss, if appropriate.
The main difference between these medications is the active ingredient. Ozempic and Wegovy use semaglutide, while Zepbound uses tirzepatide. Tirzepatide is a dual-action GLP-1 and GIP, meaning it works by activating two hormone receptors that regulate your metabolism, helping you feel full faster and longer. In comparison, semaglutide only activates the GLP-1 receptor.
What are the side effects of Zepbound?
The most common side effects of Zepbound are: nausea, diarrhea, vomiting, constipation, stomach pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching/gas, hair loss, and heartburn.
Zepbound may have serious side effects, including possible thyroid tumors. Do not use if you or your family have a history of a type of thyroid cancer called MTC or MEN 2.
Zepbound may cause other serious side effects, including severe gastrointestinal disease, kidney injury, gallbladder disease, inflammation of the pancreas, severe allergic reactions, low blood sugar, complications in patients with diabetic retinopathy, and suicidal thoughts. Zepbound may reduce the efficacy of birth control pills.
Your Ro-affiliated provider will work with you to manage any side effects.
See full Important Safety Information here.
Limited availability of some doses of Zepbound.
*Patients without diabetes and with BMI ≥30, or BMI ≥27 plus a weight-related condition, lost an average of 20% of their body weight by 1 year in a 72-week trial studying the highest maintenance dose of Zepbound (15 mg), when paired with diet and exercise changes (compared to 3% with diet and exercise alone).
Select your current weight
252lbs
Weight you could lose (lbs):
50lbs
*In a 68- and 72-week clinical trial studying Wegovy (2.4 mg) and Zepbound (15 mg) in patients without diabetes and with BMI ≥30, or BMI ≥27 with a weight-related condition, the average weight loss was 15% and 20%, when paired with diet and exercise changes (compared to 2.4% and 3.1%, respectively, with diet and exercise alone).
Which GLP-1 is right for you?
There are a number of GLP-1 medications on the market, but they all work by slowing down gastric emptying, making you feel full faster and longer.
Selecting a GLP-1 that’s right for you depends on a few factors, including your health history and insurance coverage (if you’re using insurance).
If you qualify for the Body Program, your provider will help determine which GLP-1 is the best fit for you.
Is using medication to lose weight cheating?
Learn more about potential side effects
How Ro helps you lose weight
We’re pushing every day to get medication to our patients faster. Here’s a quick rundown: It takes 4-6 weeks to start if you’re not using insurance. If your provider orders a lab test, it may extend the timeline depending on how quickly you complete the labs. If you’d like to use your insurance, it can take an additional 2-3 weeks to determine coverage. We’ll handle the paperwork and work hard to get that coverage for you.
Getting started $99
Answer health questions and complete your online visit
Share your health history and weight loss goals with us online to get started. A Ro-affiliated provider will review your answers and get back to you within a few days. Depending on your health review, a provider may order a metabolic lab test before moving forward with treatment.
Provider writes an Rx (if appropriate)
After reviewing your results, your provider will determine if you’re eligible for medication. If you are, they’ll tailor a program with prescription treatment best suited to your unique biology.
Try to get insurance coverage
If you'd like to try to use insurance, our concierge partner connects with your insurance company to help get the cost of medication covered. If coverage is denied, we'll help you understand your options, including paying cash.
Ongoing care $145/mo
Get medication
If you're prescribed compounded semaglutide, our partner pharmacy will ship your medication in 1-4 days. If you're prescribed a branded GLP-1 medication, you'll get your prescription from your preferred pharmacy.
Ongoing care and support
You’ll have everything you need during treatment, including on-demand provider access via video or messaging, medication management, and ongoing refill support.
$99 to get started $145/mo for ongoing care
What’s included
Provider consultation
GLP-1 prescription (if appropriate)
Insurance concierge
Ongoing care & support
Tools to track progress
Please note: The cost of medication is not included in the Body Program.
Dr. Pepper lost 30 lbs in 1 year
“I started losing weight almost immediately. To me, truly, this has been a game-changer.”
Dr. Pepper Ro Ambassador who inspired the Body Program, after taking GLP-1 medication
Stacie lost 49 lbs in 6 months
“I used to constantly crave food in general. I was always hungry before starting the Body Program.”
Stacie Ro member after taking GLP-1 medication
Meet our expert
From diagnosis to delivery, our healthcare providers are with patients every step of the way.
Hear from Body Program members
Ro Body Program members taking branded GLP-1 medications were paid for their testimonials.
Sonia
Ro member
“I’ve had some pretty amazing success. I’m down 15 pounds and I couldn’t be happier."
James
Ro member
“It's really helping handle my cravings better, which is what I really like about this program."
Chaleeta
Ro member
“It was like a switch once I started the medication, I just wasn’t so obsessed with food.”
Zepbound FAQs
Can I get Zepbound through the Body Program?
Yes! If you're interested in starting treatment with Zepbound, the first step of joining the Body Program is completing an online visit and then taking a lab test so that a medical provider can determine if treatment is right for you.
What are the side effects of Zepbound?
Like other GLP-1 medications, Zepbound comes with the risk of potential side effects. Most people experience these side effects when their dose is increased, and they tend to improve once a steady dose is reached. Some of the most common side effects include:
Nausea
Diarrhea
Vomiting
Constipation
Stomach pains
Upset stomach
Indigestion
Injection-site reactions
Fatigue
Belching and gas
Hair loss
Heartburn
Additionally, if you take oral birth control pills, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for 4 weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.
More severe side effects are rarer but possible. Serious side effects include:
Thyroid cancer: Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider. Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Severe stomach problems
Pancreatitis
Gallbladder disease
Rapid heartbeat
Severe allergy (hypersensitivity)
Low blood sugar
Changes in vision in patients with type 2 diabetes
Kidney disease
Suicidal thoughts or behaviors
These are not all of the possible side effects of Zepbound. For more complete information about Zepbound, including Boxed warning, see full Important Safety Information.
How do you store Zepbound?
The injection pens should be stored in the refrigerator at 36-46º F, but they may be kept between 46-86º F for up to 21 days, if needed. If you store the pen at room temperature, do not return it to the refrigerator.
Store the pens in the original packaging to protect the pen from light. Do not freeze the pens. The pen contains glass parts, so if you drop the pen on a hard surface, do not use the pen for your injection.
How much does Zepbound cost?
Insurance coverage and copays vary for Zepbound depending on your plan. Our insurance concierge will work with your provider to determine your coverage for GLP-1 medication and, if necessary, submit a prior authorization request for you. If you’re paying cash, Zepbound costs about $1,000/mo. If you have commercial insurance, you may be eligible for a discount through the manufacturer. Learn more about the Zepbound savings card here.
Your Body Program membership, which includes provider visits, ongoing coaching, and anytime messaging, is $99 for the first month and $145/mo afterwards. You’ll also need to pay for a one-time lab test. Learn more about Body Program pricing here.
How is Ro helping patients navigate GLP-1 medication shortages?
Ro and Ro-affiliated providers are following GLP-1 medication shortages closely so we can support new and existing patients on their weight loss journeys.
Your provider may make adjustments to your treatment plan if they determine it’s clinically appropriate. These adjustments may include prescribing alternate GLP-1 medications (if appropriate), working with you to create a personalized treatment plan, or recommending adjustments to diet, lifestyle, and current fitness activities.
If you’re prescribed a medication that is in short supply, you can also be added to the waitlist for medication at your preferred pharmacy.
From the experts at ro
Read more about Zepbound
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Zepbound vs. Mounjaro: What is the Difference?
6 min read
What is Zepbound? All About the Weight Loss Drug
2 min read
Does Zepbound Need to Be Refrigerated?
Zepbound 101
How does Zepbound work?
Zepbound mimics two naturally occurring hormones (GLP-1 and GIP) in your body to help you regulate your metabolism. This slows digestion and makes you feel full faster and longer. It also communicates with the part of your brain in charge of hunger to help you regulate how much you eat. On average, patients lost 20% of their body weight in a year using the highest dose of Zepbound when combined with healthy lifestyle changes.
What is Zepbound’s dosing?
If prescribed, you’ll start on the lowest dose (2.5 mg) for the first four weeks, and then work with your provider to slowly increase your dose every four weeks until you reach a steady dose that works best for you.
How do you take Zepbound?
Zepbound is a once-weekly injection that comes in a pre-filled, single-dose pen. If prescribed, you’ll receive detailed instructions from your provider on how to inject it in your stomach, arm, or thigh.
How much weight can I expect to lose with Zepbound?
In clinical trials, patients lost an average of 20% of their body weight in a year when they combined the highest dose of Zepbound with healthy lifestyle changes.
Who can use Zepbound? Who shouldn’t use it?
Zepbound is approved for weight loss in adults who either have a BMI of at least 30 or a BMI of at least 27 with a weight-related condition, like high blood pressure, type 2 diabetes, or cardiovascular disease.
How are side effects for Zepbound different from Ozempic or Wegovy?
The side effects of Zepbound are similar to Ozempic and Wegovy. However, birth control pills have been shown to be less effective when taking Zepbound. If you’re considering treatment with Zepbound, tell your provider about what contraception you’re taking. For more information about side effects, learn more here: ro.co/safety-info/zepbound
Will insurance cover Zepbound?
Some health plans cover Zepbound for weight loss, but coverage and copay amounts vary. Plans may also require prior authorization before approving coverage. If you’re interested in paying with insurance, we’ll work with your provider to help you get coverage.